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  • Quest: Why do women suffer from migraine more often than men?

    1 in 3 women will experience a migraine attack at some point in their life. Migraine is three times more common in women than in men. Where does that difference come from? Physician-researcher Britt van der Arend and neurologist Gisela Terwindt explain it in an interview with Quest magazine. Read the article here (in Dutch).

  • New publication!

    Anti-CGRP medications seem to work just as well in women with menstrual migraine as in women with migraine that is not menstrual related. This research suggests that the use of anti-CGRP (receptor) antibodies may lead to a reduction in the number of migraine days throughout all days of the menstrual cycle. The finding also supports the preventive use of these antibodies in women with menstrual migraines. The entire article can be read here.

  • This is why women are more likely to experience severe migraine attacks than men

    A third of all women will suffer from migraines during their lifetime, compared to ‘only’ one in nine men. Where do those differences come from? Libelle asked (headache) neurologist Gisela Terwindt and PhD Candidate Britt van der Arend. Read the article here (in Dutch).

  • Facts and myths about the link between headaches and food; what is true?

    Does chocolate help with migraines and does coffee cause headaches? It is often said that food can prevent, cause, worsen, or reduce headaches. What are the facts and what are the myths? Neurologist Gisela Terwindt and medical researcher Britt van der Arend gave an interview in the magazine Libelle about the relationship between food and headaches, and food and migraines. You can read the article here (in Dutch).

  • Self-reported diagnosis of "menstrual migraine" has poor accuracy, headache E-diary is needed

    New research from our group shows that self-reported menstrual migraine diagnosis has extremely poor accuracy. Two thirds of women suffer from menstrual migraine, independent of self-reports. Pure menstrual migraine is rare. Women with menstrual migraine have longer attack duration and increased triptan intake during perimenstrual attacks, in contrast to women without menstrual migraine. Prospective headache (E-)diaries are required for a menstrual migraine diagnosis, also in clinical practice. Read the article here.

  • Treatment of (menstrual) migraine in women

    Migraine is a brain disease that occurs three times more often in women than in men. Changes are also seen throughout a woman’s life course. Hormone fluctuations play a role in this, but the exact pathophysiology is still unknown. The drop in estrogen just before menstruation may lower the threshold for having a migraine attack. Migraine attacks are therefore more often seen in the period of two days before the first day of the menstrual bleeding up to three days later. These so-called perimenstrual attacks are more severe and longer of duration. As a result, the headache returns more often after taking a triptan (recurrence), because the effect duration of a triptan is too short for the duration of the migraine attack. Therefore, there is a great need for a woman-specific (hormonal) treatment for migraines. Read the full article here (in Dutch).

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Verhagen, IE, de Vries Lentsch, S, van der Arend, BWH, le Cessie, S, MaassenVanDenBrink, A, Terwindt, GM. Both perimenstrual and nonperimenstrual migraine days respond to anti-calcitonin gene-related peptide (receptor) antibodies. Eur J Neurol. 2023; 30: 2117- 2121. PubMed.

Verhagen IE, van der Arend BW, van Casteren DS, et al. Migraine with and without aura in relation to the menstrual cycle and other hormonal milestones: A prospective cohort study. Cephalalgia. 2023;43(6). PubMed.

Verhagen IE, van der Arend BWH, van Casteren DS, le Cessie S,  MaassenVanDenBrink A, Terwindt GM. Sex differences in migraine attack characteristics: A longitudinal E-diary study. Headache. 2023; 63: 333-341. PubMed.

Verhagen IE, Spaink HA, van der Arend BW, van Casteren DS, MaassenVanDenBrink A, Terwindt GM. Validation of diagnostic ICHD-3 criteria for menstrual migraine. Cephalalgia. 2022 Oct; 42(11-12): 1184-1193. PubMed.

Verhagen, I.E., Brandt, R.B., Kruitbosch, C.M.A., MaassenVanDenBrink A, Fronczek R, Terwindt GM. Clinical symptoms of androgen deficiency in men with migraine or cluster headache: a cross-sectional cohort study. Journal of Headache and Pain 22, 125 (2021). PubMed.

van Casteren DS, Verhagen IE, BWH van der Arend, EW van Zwet, MaassenVanDenBrink A, Terwindt GM. Comparing perimenstrual and nonperimenstrual migraine attacks using an E-diary. Neurology. 2021 Sep. PubMed.

van Casteren DS, Verhagen IE, Onderwater GL, MaassenVanDenBrink A, Terwindt GM. Sex differences in prevalence of migraine trigger factors: A cross-sectional study. Cephalalgia. 2021 May; 41(6):643-648. PubMed.

van Casteren DS, Kurth T, Danser AHJ, Terwindt GM, MaassenVanDenBrink A. Sex Differences in Response to Triptans: A Systematic Review and Meta-analysis. Neurology. 2021 Jan 26; 96(4):162-170. PubMed.

van Casteren DS, Verhagen IE, de Boer I, de Vries Lentsch S, Fronczek R, van Zwet EW, MaassenVanDenBrink A, Terwindt GM. E-diary use in clinical headache practice: A prospective observational study. Cephalalgia. 2021 Oct; 41(11-12): 1161-1171. PubMed.

van Casteren DS, van Willigenburg FAC, MaassenVanDenBrink A, Terwindt GM. Jealousy in women with migraine: a cross-sectional case-control study. The Journal of Headache and Pain. May 2020. PubMed.

van Casteren DS, MaassenVanDenBrink A, Terwindt GM. Migraine and other headache disorders in pregnancy. Handbook of Clinical Neurology. 2020. PubMed.