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  • Migraine Patient Day 2024

    The Leiden Headache Group organized a successful Migraine Patient Day, welcoming 300 people with Migraine logo pastries. Prof. Dr. G. Terwindt opened the day, followed by plenary sessions on various topics including the role of headache nurses, genetic research in migraine, and new treatment options. Participants could choose from interactive sessions on topics such as hormones and migraine triggers, and were given tours of the research laboratory and an EEG demonstration. The day concluded with a reception where scientific posters were presented and Headache Network provided information. Thanks to sponsors Abbvie, Lundbeck, Pfizer, and Teva, as well as all participants and their families. A report of the day will soon be available on Also, listen to the Headache Podcast for more information! The next episode, scheduled for early April, will cover this patient day!

  • Publication: rationale and protocol of the WHAT! Trial

    New publication! Our WHAT! study is moving forward with the publication of the background and protocol of the WHAT! Trial. You can find the entire article here. Women who suffer from migraines are more likely to experience migraines during their periods or other hormonal changes. The lack of understanding of the underlying pathophysiological mechanism causes a lack of hormonal treatment for migraine in women. Our hypothesis is that continuous daily use of a birth control pill could be an effective and well-tolerated preventive treatment for menstrual migraine.ūüíä We are still looking for new participants! If you are interested or know someone who might be, you can go to our application form (Dutch language is required)

  • Webinar Stichting Voices for Women

    On Jan. 29, 2024, Voices for Women Foundation held a webinar on headaches in girls and women: “could it be migraine”? The webinar was a great success and very informative. During this webinar, the Voices for Women Foundation talked with columnist and expert by experience Roos Schlikker and medical specialist Gisela Terwindt about headaches in girls and women. The WHAT! study was also discussed, as well as practical tips and advice for girls and women with migraine. You can listen back to the webinar at:

  • Quest: Why do women suffer from migraine more often than men?

    1 in 3 women will experience a migraine attack at some point in their life. Migraine is three times more common in women than in men. Where does that difference come from? Physician-researcher Britt van der Arend and neurologist Gisela Terwindt explain it in an interview with Quest magazine. Read the article here (in Dutch).

  • New publication!

    Anti-CGRP medications seem to work just as well in women with menstrual migraine as in women with migraine that is not menstrual related. This research suggests that the use of anti-CGRP (receptor) antibodies may lead to a reduction in the number of migraine days throughout all days of the menstrual cycle. The finding also supports the preventive use of these antibodies in women with menstrual migraines. The entire article can be read here.

  • This is why women are more likely to experience severe migraine attacks than men

    A third of all women will suffer from migraines during their lifetime, compared to ‘only’ one in nine men. Where do those differences come from? Libelle asked (headache) neurologist Gisela Terwindt and PhD Candidate Britt van der Arend. Read the article here (in Dutch).

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van der Arend, BWH, van Casteren, DS, Verhagen, IE et al. Continuous combined oral contraceptive use versus vitamin E in the treatment of menstrual migraine: rationale and protocol of a randomized controlled trial (WHAT!). Trials 25, 123 (2024). PubMed.

Verhagen, IE, de Vries Lentsch, S, van der Arend, BWH, le Cessie, S, MaassenVanDenBrink, A, Terwindt, GM. Both perimenstrual and nonperimenstrual migraine days respond to anti-calcitonin gene-related peptide (receptor) antibodies. Eur J Neurol. 2023; 30: 2117- 2121. PubMed.

Verhagen IE, van der Arend BW, van Casteren DS, et al. Migraine with and without aura in relation to the menstrual cycle and other hormonal milestones: A prospective cohort study. Cephalalgia. 2023;43(6). PubMed.

Verhagen IE, van der Arend BWH, van Casteren DS, le Cessie S,  MaassenVanDenBrink A, Terwindt GM. Sex differences in migraine attack characteristics: A longitudinal E-diary study. Headache. 2023; 63: 333-341. PubMed.

Verhagen IE, Spaink HA, van der Arend BW, van Casteren DS, MaassenVanDenBrink A, Terwindt GM. Validation of diagnostic ICHD-3 criteria for menstrual migraine. Cephalalgia. 2022 Oct; 42(11-12): 1184-1193. PubMed.

Verhagen, I.E., Brandt, R.B., Kruitbosch, C.M.A., MaassenVanDenBrink A, Fronczek R, Terwindt GM. Clinical symptoms of androgen deficiency in men with migraine or cluster headache: a cross-sectional cohort study. Journal of Headache and Pain 22, 125 (2021). PubMed.

van Casteren DS, Verhagen IE, BWH van der Arend, EW van Zwet, MaassenVanDenBrink A, Terwindt GM. Comparing perimenstrual and nonperimenstrual migraine attacks using an E-diary. Neurology. 2021 Sep. PubMed.

van Casteren DS, Verhagen IE, Onderwater GL, MaassenVanDenBrink A, Terwindt GM. Sex differences in prevalence of migraine trigger factors: A cross-sectional study. Cephalalgia. 2021 May; 41(6):643-648. PubMed.

van Casteren DS, Kurth T, Danser AHJ, Terwindt GM, MaassenVanDenBrink A. Sex Differences in Response to Triptans: A Systematic Review and Meta-analysis. Neurology. 2021 Jan 26; 96(4):162-170. PubMed.

van Casteren DS, Verhagen IE, de Boer I, de Vries Lentsch S, Fronczek R, van Zwet EW, MaassenVanDenBrink A, Terwindt GM. E-diary use in clinical headache practice: A prospective observational study. Cephalalgia. 2021 Oct; 41(11-12): 1161-1171. PubMed.

van Casteren DS, van Willigenburg FAC, MaassenVanDenBrink A, Terwindt GM. Jealousy in women with migraine: a cross-sectional case-control study. The Journal of Headache and Pain. May 2020. PubMed.

van Casteren DS, MaassenVanDenBrink A, Terwindt GM. Migraine and other headache disorders in pregnancy. Handbook of Clinical Neurology. 2020. PubMed.