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More diversity is needed in medicine studies for migraine
There needs to be more diversity in clinical research into anti-migraine drugs. The new generation of migraine drugs has for the most part been tested in a homogeneous population, consisting mainly of American white women with an average BMI of 30-plus. This makes the effect of the medication on people of the opposite sex, stature, ethnicity and age in fact unpredictable. Migraine scientists, Prof. Dr. Antoinette Maassen van den Brink and Dr. Linda Al-Hassany of the Department of Internal Medicine at Erasmus MC, warn against this in an opinion article in the scientific journal The Lancet Neurology. Read the article here.
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Podcast Gezond Gesprek with Gisela Terwindt about migraine
Migraine is not just a regular headache. It is a primary brain disorder, which can have severe impact on daily life. Migraine can be accompanied by an aura, and sometimes with speach disorders or sensory deficits. What can you do when you have migraine? Is it useful to ajust your life and follow a diet, or take the oral contraceptive pill? Gisela Terwindt tells you all about migraine in this podcast (in Dutch).
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Public lecture via YouTube: differences and similarities between men and women with cardiovascular disease
24 November 19.00h – https://youtu.be/d3fxD9zsdIU
The importance of a gender-specific approach to cardiovascular disease will be discussed during an online public lecture organized by the Thorax Center – Erasmus MC. Prof. dr. Eric Boersma will provide background information on the incidence of cardiovascular disease among men and women. dr. Jeanine Roeters van Lennep will talk about the relationship between pregnancy complications and the development of cardiovascular disease among middle-aged women. Prof. dr. Antoinette Maassen van den Brink discusses the relationship between migraine (a condition that mainly affects women) and cardiovascular disease. -
Is a tragus piercing effective against migraine? Prof. Dr. Terwindt explains
A tragus piercing is placed in the middle piece of cartilage of your ear, just in front of your ear canal. According to various internet forums, this tragus piercing would help against migraines, but is this true? LINDA.nl asks Gisela Terwindt, professor of Neurology and head of the Leiden Headache Center. According to her, it is just a “placebo-effect”. Read the article here (in Dutch).
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Gender en Gezondheid expert Antoinette Maassen van den Brink receives the Corrie Hermann Price 2021 - ZonMW
2 October 2021 Antoinette Maassen van den Brink (Erasmus MC) receives the Corrie Hermann Price from the Vereniging van Nederlandse Vrouwelijke Artsen (VNVA). She receives this prestigious price for her research in migraine and female hormones. Thereby, she contributes to gender- and sex sensitive research for medical care and health. Read the article here (in Dutch).
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Menstrual migraine: interview in Period!
A unilateral, throbbing headache which gets worse with exerting. Nausea and vomiting. Difficulties concentrating. Sensitivity for light and sounds. For a lot of women this is monthly practice. Migraine affects women three times more often than men. Hormones are of influence. But how? Pharmacologist Antoinette Maassen van den Brink from the Erasmus MC in Rotterdam tells more about this phenomenon in Period! Read the full article here (in Dutch).
Publicaties
van der Arend, BWH, van Casteren, DS, Verhagen, IE et al. Continuous combined oral contraceptive use versus vitamin E in the treatment of menstrual migraine: rationale and protocol of a randomized controlled trial (WHAT!). Trials 25, 123 (2024). PubMed.
Verhagen, IE, de Vries Lentsch, S, van der Arend, BWH, le Cessie, S, MaassenVanDenBrink, A, Terwindt, GM. Both perimenstrual and nonperimenstrual migraine days respond to anti-calcitonin gene-related peptide (receptor) antibodies. Eur J Neurol. 2023; 30: 2117- 2121. PubMed.
Verhagen IE, van der Arend BW, van Casteren DS, et al. Migraine with and without aura in relation to the menstrual cycle and other hormonal milestones: A prospective cohort study. Cephalalgia. 2023;43(6). PubMed.
Verhagen IE, van der Arend BWH, van Casteren DS, le Cessie S, MaassenVanDenBrink A, Terwindt GM. Sex differences in migraine attack characteristics: A longitudinal E-diary study. Headache. 2023; 63: 333-341. PubMed.
Verhagen IE, Spaink HA, van der Arend BW, van Casteren DS, MaassenVanDenBrink A, Terwindt GM. Validation of diagnostic ICHD-3 criteria for menstrual migraine. Cephalalgia. 2022 Oct; 42(11-12): 1184-1193. PubMed.
Verhagen, I.E., Brandt, R.B., Kruitbosch, C.M.A., MaassenVanDenBrink A, Fronczek R, Terwindt GM. Clinical symptoms of androgen deficiency in men with migraine or cluster headache: a cross-sectional cohort study. Journal of Headache and Pain 22, 125 (2021). PubMed.
van Casteren DS, Verhagen IE, BWH van der Arend, EW van Zwet, MaassenVanDenBrink A, Terwindt GM. Comparing perimenstrual and nonperimenstrual migraine attacks using an E-diary. Neurology. 2021 Sep. PubMed.
van Casteren DS, Verhagen IE, Onderwater GL, MaassenVanDenBrink A, Terwindt GM. Sex differences in prevalence of migraine trigger factors: A cross-sectional study. Cephalalgia. 2021 May; 41(6):643-648. PubMed.
van Casteren DS, Kurth T, Danser AHJ, Terwindt GM, MaassenVanDenBrink A. Sex Differences in Response to Triptans: A Systematic Review and Meta-analysis. Neurology. 2021 Jan 26; 96(4):162-170. PubMed.
van Casteren DS, Verhagen IE, de Boer I, de Vries Lentsch S, Fronczek R, van Zwet EW, MaassenVanDenBrink A, Terwindt GM. E-diary use in clinical headache practice: A prospective observational study. Cephalalgia. 2021 Oct; 41(11-12): 1161-1171. PubMed.
van Casteren DS, van Willigenburg FAC, MaassenVanDenBrink A, Terwindt GM. Jealousy in women with migraine: a cross-sectional case-control study. The Journal of Headache and Pain. May 2020. PubMed.
van Casteren DS, MaassenVanDenBrink A, Terwindt GM. Migraine and other headache disorders in pregnancy. Handbook of Clinical Neurology. 2020. PubMed.