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The migraine WHAT! study focusses on the role of hormones in women with migraine. WHAT stands for “Women, Hormones, Attacks and Treatment”.

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  • Quest: Why do women suffer from migraine more often than men?

    1 in 3 women will experience a migraine attack at some point in their life. Migraine is three times more common in women than in men. Where does that difference come from? Physician-researcher Britt van der Arend and neurologist Gisela Terwindt explain it in an interview with Quest magazine. Read the article here (in Dutch).

  • New publication!

    Anti-CGRP medications seem to work just as well in women with menstrual migraine as in women with migraine that is not menstrual related. This research suggests that the use of anti-CGRP (receptor) antibodies may lead to a reduction in the number of migraine days throughout all days of the menstrual cycle. The finding also supports the preventive use of these antibodies in women with menstrual migraines. The entire article can be read here.

  • This is why women are more likely to experience severe migraine attacks than men

    A third of all women will suffer from migraines during their lifetime, compared to ‘only’ one in nine men. Where do those differences come from? Libelle asked (headache) neurologist Gisela Terwindt and PhD Candidate Britt van der Arend. Read the article here (in Dutch).

  • Facts and myths about the link between headaches and food; what is true?

    Does chocolate help with migraines and does coffee cause headaches? It is often said that food can prevent, cause, worsen, or reduce headaches. What are the facts and what are the myths? Neurologist Gisela Terwindt and medical researcher Britt van der Arend gave an interview in the magazine Libelle about the relationship between food and headaches, and food and migraines. You can read the article here (in Dutch).

  • Self-reported diagnosis of "menstrual migraine" has poor accuracy, headache E-diary is needed

    New research from our group shows that self-reported menstrual migraine diagnosis has extremely poor accuracy. Two thirds of women suffer from menstrual migraine, independent of self-reports. Pure menstrual migraine is rare. Women with menstrual migraine have longer attack duration and increased triptan intake during perimenstrual attacks, in contrast to women without menstrual migraine. Prospective headache (E-)diaries are required for a menstrual migraine diagnosis, also in clinical practice. Read the article here.

  • Treatment of (menstrual) migraine in women

    Migraine is a brain disease that occurs three times more often in women than in men. Changes are also seen throughout a woman’s life course. Hormone fluctuations play a role in this, but the exact pathophysiology is still unknown. The drop in estrogen just before menstruation may lower the threshold for having a migraine attack. Migraine attacks are therefore more often seen in the period of two days before the first day of the menstrual bleeding up to three days later. These so-called perimenstrual attacks are more severe and longer of duration. As a result, the headache returns more often after taking a triptan (recurrence), because the effect duration of a triptan is too short for the duration of the migraine attack. Therefore, there is a great need for a woman-specific (hormonal) treatment for migraines. Read the full article here (in Dutch).

  • Migraine topic in magazine "Medisch Contact"

    Women in particular suffer from migraines, yet little is known about the causes and sex-specific treatment of migraine in women. Physicians and researchers of the Leiden University Medical Center and Erasmus MC are now changing that. They investigate the influence of sex hormones in women with migraine and look for the optimal therapy. Read the article here (in Dutch).

  • Article in magazine Margriet: migraine in women is more than "just a headache"

    One out of three women experiences migraine, a brain disorder which occurs three times more often in women than in men. And that is exactly where it goes wrong: because health care is mainly based on the male body, treatment is insufficiently adapted to women. We believe that this subject deserves more attention in healthcare, certainly in combination with more specific attention for women in neurological disorders and in particular migraine. Read the article here (in Dutch).

  • Migraine special: genetics and hormones

    Everybody can suffer from a migraine attack once in a while, but the risk is not the same for everybody. Genetics play a role, but also sex hormones can be linked to an increased risk. In this interview, prof. Gisela Terwindt, and physician researchers Irene de Boer and Iris Verhagen, share their insights and recent research developments.

  • More diversity is needed in medicine studies for migraine

    There needs to be more diversity in clinical research into anti-migraine drugs. The new generation of migraine drugs has for the most part been tested in a homogeneous population, consisting mainly of American white women with an average BMI of 30-plus. This makes the effect of the medication on people of the opposite sex, stature, ethnicity and age in fact unpredictable. Migraine scientists, Prof. Dr. Antoinette Maassen van den Brink and Dr. Linda Al-Hassany of the Department of Internal Medicine at Erasmus MC, warn against this in an opinion article in the scientific journal The Lancet Neurology. Read the article here.

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